September 29th, 2008
By Suna Özdemira, Hüseyin Görkemlia, Kazim Gezginça, Mustafa Özdemirb, Aysel Kiyicic
International Journal of Gynecology & Obstetrics
Volume 103, Issue 1, Pages 44-49 (October 2008)
Abstract
Objectives: To investigate the effects of treatment with medroxyprogesterone acetate (MPA), 10 days per month for 6 months, on lipid and carbohydrate metabolism in women with polycystic ovary syndrome (PCOS). Methods: Sixty-three women with PCOS were randomized to receive MPA or ethinyl estradiol plus drospirenone. Results: There were no changes in lipid or carbohydrate metabolism in the MPA group, but serum levels of luteinizing hormone (P<0.001) and total testosterone (P<0.003) significantly decreased, as did the free androgen index (P<0.02) and acne (P<0.03) and seborrhea (P<0.04) scores. In the ethinyl estradiol plus drospirenone group lipid and hormone values significantly increased whereas acne, seborrhea, hair loss, and Ferriman-Gallwey scores decreased. There was no statistically significant change in the total cholesterol to high-density cholesterol ratio in either group. Conclusion: Treatment of PCOS patients with MPA provided good menstrual cycle control, beneficial changes in hormonal values associated with hyperandrogenism, and no significant changes in lipid or carbohydrate metabolism.
September 25th, 2008
Kent, Sarah C.; Gnatuk, Carol L.; Kunselman, Allen R.; Demers, Laurence M.; Lee, Peter A.; Legro, Richard S. Obstetrical & Gynecological Survey. 63(10):646-647, October 2008.
Abstract:
Both hyperandrogenism and insulin resistance are heritable family traits that may cluster in children whose mothers have polycystic ovary syndrome (PCOS). This case control study compared reproductive and metabolic abnormalities in 32 healthy “PCOS children,” 17 girls and 15 boys, and 38 children whose mothers did not have PCOS. The children ranged in age from 4 to 14 years. There were no differences between PCOS and control children in the length of gestation or birth weight.
Urinary levels of luteinizing hormone were significantly lower in Tanner IV-V PCOS girls than in control subjects. Urinary testosterone levels were significantly greater in Tanner II-III PCOS boys than in controls. No significant differences in levels of dehydroepiandrosterone (DHEA) or DHEA sulfate were observed. Fasting insulin levels did not differ significantly between PCOS and control children of either gender, whether saliva or blood samples were analyzed. Nevertheless, mean area-under-the-curve salivary insulin levels were significantly higher in Tanner IV-V PCOS girls in the later stages of puberty than in control children. Five of 15 PCOS children met the de Ferranti criteria for metabolic syndrome, compared to only one of 12 control children. No children in either group met criteria for abnormal fasting blood glucose. Although ovaries tended to be larger in PCOS girls, none of the children examined by transabdominal ultrasonography had evidence of polycystic ovaries based on morphological criteria.
This study suggests that hyperinsulinism may be a familial feature of PCOS children – at least girls – but it does not emerge until the later stages of puberty. It is possible that reproductive abnormalities characteristic of PCOS will develop later in life.
C) 2008 Lippincott Williams & Wilkins, Inc.
http://www.obgynsurvey.com/pt/re/obgynsurv/currenttoc.htm
September 24th, 2008
CNN.COM/entertainment
Sept. 24, 2008
- Nicole Kidman says swimming in Australian Outback waterfalls may promote fertility
- 41-year-old actress gave birth to daughter Sunday Rose in July
- Kidman swam in the waters during production of the epic romance “Australia”
- “Seven babies were conceived out of this film,” she says
SYDNEY, Australia (AP) — Oscar-winning actress Nicole Kidman said swimming in Australian Outback waterfalls may promote fertility and might have contributed to her unexpected pregnancy over the past year.
The 41-year-old Aussie, who gave birth to daughter Sunday Rose in July, said she and six other women who swam in the waters of a small Outback town during production of the epic romance “Australia” became pregnant.
“I never thought that I would get pregnant and give birth to a child, but it happened on this movie,” Kidman told The Australian Women’s Weekly in an exclusive interview for the magazine’s 75th anniversary edition, released Wednesday.
“Seven babies were conceived out of this film and only one was a boy. There is something up there in the Kununurra water because we all went swimming in the waterfalls, so we can call it the fertility waters now.”
“Australia,” directed by Baz Luhrmann, was filmed in Kununurra, a small town in far northern Western Australia state. The film, which follows the story of a noblewoman on a cattle drive in Australia during World War II, is due for release in November.
The actress also commented on the relatively diminutive size of her baby bump throughout her pregnancy.
“I’m so lucky I’m so tall, so I carried small and also, I have to say, I had a birth that I was blessed with, a labor that was very good and a baby that was very good to me in that regard,” said Kidman, who is married to country music crooner Keith Urban and has two adopted children with ex-husband Tom Cruise.
“To be given this again is a beautiful thing. To have raised Bella and Connor since I was 25 and now to be able to do it again at 41 … wow!”
http://www.cnn.com/2008/SHOWBIZ/09/24/kidman.fertile.water.ap/index.html
September 24th, 2008
Obese women may have a harder time becoming pregnant, reports CNN’s Dr. Sanjay Gupta.
August 24, 2008
sourced from CNN.com
