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Metformin (Glucophage) and PCOS


Do you understand the side effects of these drugs?

"I have been on the Insulite PCOS system for a little over 3 months now and it is truly a miracle. I feel energized, healthy, and most importantly: normal. I'm on my 2nd consecutive menstrual cycle which hasn't happened since I was a teenager or without the help of birth control pills. Amazing! I never thought this would happen.

Thank you to all of those who have taken the time and energy to put together a system that can help people feel normal and enjoy life the way you should. Not to mention all the ingredients in the Insulite PCOS System are healthy and can be taken without having any negative side effects. I'm forever in debt!"
Heather Siegle
  Waukee, IA

PCOS Medical ProfessionalThis web site includes an abundance of research and detailed information on PCOS, its causes, effects, and what you can do to improve your health - naturally. In order to provide you easy choices in learning about PCOS and Metformin we've provided "a Short Version" with the key information. For those of you who wish to read more in depth detail please read "The Whole Story" below.

We have also included four boxes (links) that provide a pathway to easily navigate a few key pages on this site. Please choose whichever path is most useful to you.

OUR COMMITMENT TO YOU

Before you read the Short and/or Long Version on PCOS and Metformin, please know we are committed help you every step of the way in your quest to reverse your PCOS and its related symptoms.

The Short Story Version"The Short Version"

Metformin (Glucophage) is a pharmaceutical drug that was originally developed to treat elevated blood glucose levels in people with type 2 diabetes. It is now commonly prescribed for women with PCOS.

Potential side effects include:

  • Many women prescribed Metformin must discontinue its use due to the gastrointestinal side effects such as diarrhea, gas and bloating, abdominal discomfort, nausea, and vomiting
  • Inhibiting of Vitamin B12 absorption - potentially lead to anemia
  • Increased levels of amino acids found in the blood, which is a risk factor for atherosclerosis
  • The contraindications in using Metformin include liver failure, alcoholism, compromised renal function, hypoxic conditions and moderate to severe infections.

There is a safe, effective alternative to using Metformin.

Click below to learn about Insulite's PCOS System



The Whole Story Version"The Whole Story"

PCOS and MetforminMetformin (Glucophage) is a pharmaceutical drug often prescribed for women with PCOS (Polycystic Ovarian Syndrome). It is an insulin-sensitizing biguanide commonly used to treat elevated blood glucose levels in people with Type 2 Diabetes and often employed as an off-label prescription for PCOS. This means that it was originally used only for individuals with Type 2 Diabetes but is now prescribed for PCOS patients because it has similar actions in both groups.

If you have PCOS, you may be insulin resistant. With this condition, the ability of your cells to respond to the action of insulin in transporting glucose (sugar) from the blood stream into muscle and tissue is greatly diminished. Metformin improves the cell's response to insulin, and helps move glucose into the cell. As a result, your body will not be required to make as much insulin (1).

PCOS and Metformin Studies

PCOS and it's symptoms of hyperandrogenism (acne, hirsutism, alopecia), reproductive disorders (irregular menses, anovulation, infertility, polycystic ovaries), and metabolic disturbances (weight gain) have been linked to hyperinsulinemia and Insulin Resistance (2). Therefore, it makes sense for you to address the hyperinsulinemia and Insulin Resistance caused by this condition.

Studies have reported the treatment of Metformin to improve hirsutism, induce ovulation and normalize menstrual cycles (1). For example, according to one study, which looked at 39 women with Polycystic Ovarian Syndrome and hyperinsulinemia (excess insulin in the blood), treatment with Metformin for women with PCOS resulted in a decline of insulin as well as total and free testosterone, leading to significant improvement of clinical manifestations of Hyperandrogenism (the excessive production of androgens in women) and an improvement in menstrual cycles (3). However, studies have also shown weight loss through exercise and changes in diet and lifestyle alone to be as effective in regulating menstrual cycles and showing improvement in hyperandrogenism (4, 5).

Metformin - Side Effects

Many women prescribed Metformin must discontinue its use due to the gastrointestinal side effects. The most commonly reported adverse effects you may experience include diarrhea, gas and bloating, abdominal discomfort, nausea, and vomiting (1, 6). Another consideration of Metformin therapy is its effect on B12 absorption. Ten - 30% of people receiving long term Metformin therapy develop B12 malabsorption, which could potentially lead to anemia.

It has also been shown that treatment with Metformin may increase your homocysteine levels (amino acids found in the blood), which is a risk factor for atherosclerosis or fatty deposits in blood vessels (7).

The contraindications in using Metformin include liver failure, alcoholism, compromised renal function, hypoxic conditions and moderate to severe infections. These conditions predispose you to having lactic acidosis, which is a life-threatening complication and carries a mortality rate of 30% - 50% (1).

A Complete System for Reversing Your PCOS

"Thank you for such a quick response- you guys are awesome to work with- I've given your website to my doctor and she is impressed and anxious to look at the PCOS system too!"
SW
  Illinois

Insulite Laboratories' view on the pharmaceutical treatment of Polycystic Ovarian Syndrome - including Metformin - is that there is no one drug on the market that will change your condition. The only way to reverse the disorder is to reduce elevations in insulin which directly affect your testosterone and other hormonal changes that are responsible for causing PCOS. Metformin can impact weight loss, infertility, acne and other PCOS-related symptoms however, the results are variable. There are also many negative side effects with the treatment of Metformin that can impact your health.

To address the cause of Polycystic Ovarian Syndrome and Insulin Resistance, the Insulite PCOS System has several elements. The PCOS + formula is designed to reduce circulating testosterone, increase sex hormone binding globulin and support your liver function and hormone metabolism. The other elements are designed to reduce your insulin secretion, reverse damage to the cardiovascular system due to imbalances in glucose and insulin and prevent insulin and glucose spiking during mealtimes. Nutritional and exercise guidelines are provided along with a support network to enhance your weight loss success as this is a critical step in reversing Polycystic Ovarian Syndrome.

The Insulite PCOS System has been designed specifically for women like you with PCOS. Because the genesis of most ovarian cysts is affected by insulin, the Insulite PCOS System is an important strategy for reducing not only the condition but also Insulin Resistant, a root cause of Polycystic Ovarian Syndrome.



You may be interested in some of our Frequently Asked Questions (FAQs) on infertility.
"I wanted to let you know how much I appreciate your caring advice and guiding me towards taking control of my health. It's hard to express in words how long I have been trying to find the answers you have so easily provided for me.

I am only 27 and was really feeling the effects of my IR and PCOS, with terrible lethargy and fearing that I would never get my active life back. I was taking glucophage which did nothing for me but cause stomach and bowel problems. After 2 1/2 weeks on Insulite PCOS, I feel an amazing difference in energy and even a little in my weight.

I am so excited about the positive changes in my health and I can't wait to see where I am six months from now, yet alone the year. Thank you again!"
MS
  Stuarts Draft, VA




(1) Metformin: an update - Kirpichnikov D, McFarlane SI, Sowers JR.
Ann Intern Med. 2002 Jul 2;137(1):25-33. Review.


(2) Metformin treatment of PCOS during adolescence and the reproductive period - La Marca A, Artensio AC, Stabile G, Volpe A.
Eur J Obstet Gynecol Reprod Biol. 2005 Jul 1;121(1):3-7


(3) ) Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome
- Kolodziejczyk B, Duleba AJ, Spaczynski RZ, Pawelczyk L., Fertil Steril. 2000 Jun;73(6):1149-54 .


(4) Combined lifestyle modification and metformin in obese patients with polycystic ovary syndrome.
A randomized, placebo- controlled, double-blind multicentre study
- Tang T, Glanville J, Hayden CJ, White D, Barth JH, Balen AH., Hum Reprod. 2005 Sep 30


(5) Should patients with polycystic ovarian syndrome be treated with metformin? A note of cautious optimism
- Homburg R., Hum Reprod. 2002 Apr;17(4):853-6. Review


(6) Metformin in polycystic ovary syndrome: systematic review and meta-analysis
- Lord JM, Flight IH, Norman RJ., BMJ. 2003 Oct 25;327(7421):951-3. Review


(7) Homocysteine and steroids levels in metformin treated women with polycystic ovary syndrome
- Vrbikova J, Bicikova M, Tallova J, Hill M, Starka L., Exp Clin Endocrinol Diabetes. 2002 Apr;110(2):74-6


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"I started taking Insulite PCOS system in early November 2005 after hearing about you through the internet and by the end of December I was pregnant. I am just thrilled that I have been so lucky and don't know what I would have done if I hadn't discovered Insulite and I want to thank you all very much for helping me achieve my wish."
Katie McKay
  England
PCOS a Leading Cause of Infertility
"I have been on the Insulite PCOS system for a little over 3 months now and it is truly a miracle. I feel energized, healthy, and most importantly: normal. A couple of months ago I decided to go off the birth control pill just to see if I could get a period on my own. I'm on my 2nd consecutive menstrual cycle which hasn't happened since I was a teenager or without the help of birth control pills. I'm currently 30 years old and am having periods on my own, Amazing! I never thought this would happen. Especially since both my daughters were conceived with the help of Glucophage and Clomid.

Thank you to all of those who have taken the time and energy to put together a system that can help people feel normal and enjoy life the way you should. Not to mention all the ingredients in the Insulite PCOS System are healthy and can be taken without having any negative side effects. I'm forever in debt!"
Heather Siegle
  Waukee, IA
"In three weeks I have lost 3 pounds, my sugar level has dropped about 10 points on average, my face has cleared up dramatically, and I feel a lot better overall.

"I have told everyone I know about your product and I have been a walking billboard this week! I have had several compliments on my new found appearance...color in my checks, very little acne and my face looks great and even with just 3 pounds gone people are asking me if I have lost weight !

"I think that every woman that even thinks she may have PCOS needs to know about your products. Especially the women who have been told that they cannot have children because of infertility from PCOS. Every woman should have the joy of having a child and with PCOS that is a very rare occasion.

"I believe in your product and I would like to get it out there so women will have a choice."
Nina Madewell
  Dickson, TN
"Your internet site has been so educational and made me realize that I'm not going mad and there is a way to control this PCOS.

Although I have never met any of your staff I feel that I get more positive response from you all than my doctors for the last five years.

I'm just so grateful for your organization. You have given me so much hope and something to look forward to. I feel as if I'm dealing with professionals who care about what happens to their patient."

As women it's vital for us to look good and feel good. It's part of our make up; it's what makes us thrive. This is not about being vain - this is about well being and confidence."
Daniella McKnight
  England
"For obese PCOS women weight loss of more than 5% of pretreatment weight restores menstrual regularity in 89%, of whom 30% achieved spontaneous pregnancy."
Saleh AM, Khalil HS. Review of non-surgical and surgical treatment and the role of insulin-sensitizing agents in the management of infertile women with polycystic ovarian syndrome. Acta Obstet Gynecol Scand. 2004 Jul;83(7):614-621.
"I just recently started the program and can already tell a difference. The acne I've been plagued with since my early teens is almost completely gone and my facial hair hasn't grown out at all this week. On top of all that, I have also made changes in my diet and exercise and have lost 10 lbs. already!"

"Until I found your web site, I never realized that there were alternatives to surgery or that Insulin Resistance was the cause of PCOS. Everything finally made sense to me."
TJ
  Dallas, TX
"So far I am very, very happy with my results. Per my hairdresser I have new hair coming in. The greatest things to me are I have had 4 cycles all on my own and my sex drive is increasing!"
KW
  Check, VA
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"First of all, I am thankful to INSULITE LABS research for such a wonderful recovery plan for patients with PCOS. I have been on the supplements for less than 10 days and I already notice some physical changes -- including reduced acne and body weight.

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"I would like to tell you how happy I am with the results I have seen in myself for the past three months since I started the Insulite System.

"I am starting my fourth month and have now lost 23 lbs. and 3-5 inches. Plus, for the first time in my life I have had my period for two consecutive months and they didn’t last as long as usual. Of course, my acne and facial hair have lessened also."
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